Saytzeff's Rule

Saytzeff Rule implies that base-induced eliminations (E₂) will lead predominantly to the olefin in which the double bond is more highly substituted, i.e. that the product distribution will be controlled by thermodynamics.

The use of sterically hindered bases raises the activation energy barrier for the pathway to the product predicted by Saytzeff's Rule. Thus, a sterically hindered base will preferentially react with the least hindered protons, and the product distribution will be controlled by kinetics.

THIS RULE OS VERY IMPORTANT FROM THE IIT POINT OF VIEW AND HAS BEEN REPEATEDLY ASKED IN PREVIOUS YEAR PAPERS. IT IS ONE OF THE BASIC RULES WE HAVE TO KEEP IN MIND WHILE DOING ORGANIC REACTIONS.