Wednesday, April 22, 2020

FRIEDEL-CRAFTS ALKYLATION

Friedel-Crafts Alkylation




This Lewis acid-catalyzed electrophilic aromatic substitution allows the synthesis of alkylated products via the reaction of arenes with alkyl halides or alkenes. Since alkyl substituents activate the arene substrate, polyalkylation may occur. A valuable, two-step alternative is Friedel-Crafts Acylation followed by a carbonyl reduction.



Mechanism of the Friedel-Crafts Alkylation





Using alkenes :




Recent Literature




Iron Oxide Nanoparticles Grown on Carboxy-Functionalized Graphite: An Efficient Reusable Catalyst for Alkylation of Arenes




Dicationic Electrophiles from Olefinic Amines in Superacid




Benzylic Phosphates in Friedel-Crafts Reactions with Activated and Unactivated Arenes: Access to Polyarylated Alkanes




Samarium Triflate-Catalyzed Halogen-Promoted Friedel-Crafts Alkylation with Alkenes




Dramatic Enhancement of Catalytic Activity in an Ionic Liquid: Highly Practical Friedel-Crafts Alkenylation of Arenes with Alkynes Catalyzed by Metal Triflates




MA-Silica Gel Catalyzed Propargylation of Aromatic Compounds with Arylpropargyl Alcohols under Solvent-Free Conditions




Iron-Catalyzed Synthesis of Tetrahydronaphthalenes via 3,4-Dihydro-2H-pyran Intermediates




Metal-Free Tandem Friedel–Crafts/Lactonization Reaction to Benzofuranones Bearing a Quaternary Center at C3 Position




Addition of Arylboronic Acids to Arylpropargyl Alcohols en Route to Indenes and Quinolines




Conversion of 2-Alkylcinnamaldehydes to 2-Alkylindanones via a Catalytic Intramolecular Friedel-Crafts Reaction

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