Friday, April 24, 2020

HENRY REACTION

Henry Reaction





The Henry Reaction is a base-catalyzed C-C bond-forming reaction between nitroalkanes and aldehydes or ketones. It is similar to the Aldol Addition, and also referred to as the Nitro Aldol Reaction.

If acidic protons are available (i.e. when R = H), the products tend to eliminate water to give nitroalkenes. Therefore, only small amounts of base should be used if the isolation of the β-hydroxy nitro-compounds is desired.



Mechanism of the Henry Reaction






Recent Literature




A Highly Diastereo- and Enantioselective Copper(I)-Catalyzed Henry Reaction Using a Bis(sulfonamide)-Diamine Ligand




A New Catalyst for the Asymmetric Henry Reaction: Synthesis of β-Nitroethanols in High Enantiomeric Excess




Practical Asymmetric Henry Reaction Catalyzed by a Chiral Diamine-Cu(OAc)2 Complex




A New Copper Acetate-Bis(oxazoline)-Catalyzed, Enantioselective Henry Reaction




Enantioselective Nitroaldol Reaction of α-Ketoesters Catalyzed by Cinchona Alkaloids




Nitroaldol Reaction in Aqueous Media: An Important Improvement of the Henry Reaction




Hyperbranched Polyamines: Tunable Catalysts for the Henry Reaction




Indium-Catalyzed Henry-Type Reaction of Aldehydes with Bromonitroalkanes




A Convenient Samarium-Promoted Synthesis of Aliphatic (E)-Nitroalkenes under Mild Conditions




Highly anti-Selective Asymmetric Nitro-Mannich Reactions Catalyzed by Bifunctional Amine-Thiourea-Bearing Multiple Hydrogen-Bonding Donors



Dinuclear Zinc-AzePhenol Catalyzed Asymmetric Aza-Henry Reaction of N-Boc Imines and Nitroalkanes under Ambient Conditions




Aza-Henry Reaction of Ketoimines Catalyzed by Na2CO3: An Efficient Way to β-Nitroamines




Electrochemically Induced Aza-Henry Reaction: A New, Mild, and Clean Synthesis of α-Nitroamines




Mechanistic Studies on the Michael Addition of Amines and Hydrazines To Nitrostyrenes: Nitroalkane Elimination via a Retro-aza-Henry-Type Process

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